姓名：杜智宏
职称：副教授
邮箱：duzhihong@shzu.edu.cn，1277752137@qq.com（优先推荐）
实验室：科技楼418
办公室地址：科技楼410
通讯地址：新疆石河子市北四路221号英国正版365
个人主页：
一、个人简介
杜智宏，男，汉族，中共党员，副教授、硕士研究生导师。主持国家自然科学基金--青年项目1项，兵团重点研发计划项目1项，兵团自然科学计划项目—面上项目1项，石河子大学青年拔尖人才计划项目1项，石河子大学高层次人才科研启动项目1项，入选新疆维吾尔自治区天池英才计划（青年博士）。参与国家社科基金1项，师市科技项目2项。在公开发行的学术刊物上发表本研究领域学术论文30余篇。目前主讲本科生课程《大学化学B》、《环境化学》和《有机化学》，主讲研究生课程《催化化学》。
二、研究方向：
1. 手性催化剂（包括生物酶仿生催化剂）及配体的设计与开发
2. 精细化学品的绿色合成与开发（包括乙醛酸及其下游产品、R-泛解酸内酯、氨基酸）
3. 手性有机框架材料（CCOF）的开发与应用。
三、招生专业：0730 化学（每年2-3人，欢迎对有机化学感兴趣的本科生来实验室读研或者交流）
四、教育经历:
2015.09-2021.09 兰州大学 生物化学与分子生物学专业 博士
2011.09-2015.07 长江大学 生命科学学院生物技术专业 学士
五、工作经历:
2023.06—至 今： 英国正版365环工系 副教授 硕士研究生导师
期 间： 2025年1月至2026年1月，在兵团科技局跟班学习
2022.09—2023.06： 英国正版365环工系 副教授
2021.09—2022.09： 英国正版365环工系 讲 师
六、科研项目
1. 兵团重点研发计划项目—攻关项目，2025AB023，2025-2028年，180万，主持，在研。
2. 兵团自然科学计划项目—面上项目，2025DA044，2025-2028年，经费30万，主持，在研。
3. 石河子大学科技计划项目—青年拔尖计划项目，BJZK20241，10万，2025-2027，主持，在研。
4. 国家自然科学基金-青年基金，非均相肽催化剂的设计合成及其在连续流不对称Aldol反应中的应用，No. 22201186, 2023.01-2025.12，30万元，结题。
5. 新疆自治区天池英才计划(青年博士项目)，具有C2-轴对称结构的手性伯胺催化剂的设计合成及应用，2023.01-2025.12，60万元，结题。
6. 石河子大学高层次人才启动项目，手性棉酚催化剂的设计开发及其在不对称仿生催化甘氨酸α-位官能化反应中的应用, No. 2022ZK005, 2022.05-2025.05，10万元，结题。
七、学术论文及专著：
专著
1. Da, Chao-Shan; Du, Zhi-Hong; Wang, Pei. 3.05 - The Aldol Reaction: Organocatalytic Approach. In Comprehensive Organic Synthesis (Third Edition), Molander, G., Knochel, P. Eds.; 250-336, , Elsevier, 2025; pp 250-336.
论文
2026年度
1. Wang，Zhuo-Yi； Chen，Fei； Bo，Chunbo； Li，Min； Liu，Ning； Du, Zhi-Hong*. Amine-Catalyzed [3+3] Annulation Reaction Between α-Alkylidene Pyrazolinones and α,β-Unsaturated Aldehydes for the Construction of Spiropyrazolones，Synthesis, 2026.
2. 王文龙, 温家旭, 陈飞, 薄春博, 李敏, 刘宁*, 杜智宏*. 铜催化的3-羟基-2-萘甲酸酯的不对称氧化偶联反应：氨基酸类配体的设计与优化. 有机化学, 2026, 10.6023/cjoc202505013.
3. Wen，Jia-Xu； Chen，Fei； Bo，Chunbo； Li，Min； Liu，Ning； Du, Zhi-Hong*. Chiral Copper Complex-Catalyzed Enantioselective Oxidative Cross-Coupling of 2 Naphthols for Synthesis of C1 Symmetric BINOLs，The Journal of Organic Chemistry 2025, 90(49), 17285–17293.
4. Zhao, Peng-Fei; Wang, Ke; Wen, Jia-Xu; Zhu, Zhang-Mei-Duo; Zhang, Hua; Wang, Zi-Heng; Liao, Yu-Xin; Da, Chao-Shan; Du, Zhi-Hong*. Recent advances in chiral phosphoric acids for asymmetric organocatalysis: a catalyst design perspective. Organic & Biomolecular Chemistry,2025, 23 (35), 7872-7913.
5. Yuan, Meng; Liu, Yang-Xin; Ding, Tie-Ying; Zhang, Ze-Xuan; Lian, Tian-Rui; Zhao, Peng-Fei; Du, Zhi-Hong; Da, Chao-Shan. Suppression of rapid deactivation of catalytic tetrapeptides in the asymmetric Michael addition of aldehydes to nitroolefins by supporting them on polymers. Organic & Biomolecular Chemistry, 2025, 23 (28), 6819-6831.
6. Yuan, Meng; Ding, Tie-Ying; Liu, Yang-Xin; Du, Zhi-Hong; Lian, Tian-Rui; Da, Chao-Shan. Resin-supported peptide-catalyzed asymmetric aldol reaction of aldehydes for the synthesis of (R)-pantolactone. Organic & Biomolecular Chemistry, 2025, 23 (25), 6191-6199.
7. Wu, Di; Wang, Yang; Tao, Sheng; Wang, Tao; Chen, Fei; Du, Zhi-Hong; Bo, Chun‐Bo; Li, Min; Dai, Bin; Wei, Donghui; et al. N-Heterocyclic Carbene-Diboron-Substrate Cooperatively Facilitate Direct Amidation of Carboxylic Acids and Amines. Advanced Synthesis & Catalysis, 2025, 367 (11), e202401441.
8. Wang, Yao; Du, Zhi-Hong; Bo, Chunbo; Li, Min; Chen, Fei; Liu, Ning. Synthesis of α,β‐Unsaturated Carbonyl Compounds via Cu/TEMPO/O2 Aerobic Catalytic System. Chemistry - A European Journal, 2025, 31 (11), e202403950.
9. Wang, Wen-Long; Lv, Xiao-Xiong; Chen, Fei; Liu, Ning; Du, Zhi-Hong*. Copper–amine-complex-catalyzed highly selective oxidative cross-coupling of 2-naphthols: Synthesis of C1-Symmetric BINOLs. Tetrahedron, 2025, 174, 134495.
10. Wang, Tao; Wu, Di; Chen, Fei; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Liu, Ning. Molecular molybdenum catalyst covalently anchored onto a polystyrene resin for the alkylation of alcohols with ketones. Fuel, 2025, 400, 135679.
11. Tao, Sheng; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Chen, Fei; Liu, Ning. Base-free catalytic systems achieved via the design of copper complexes: synthesis of 2-oxazolidinones from propargylic amines and CO2. New Journal of Chemistry, 2025, 49 (37), 16122-16133.
12. Shen, Yang-Yang; Li, Xiao-Bin; Chen, Fei; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Liu, Ning. Dehydrogenation of Aromatic Alcohols, Aldehydes, and Ketones Catalyzed by Cu(I) Complexes. The Journal of Organic Chemistry, 2025, 90 (7), 2644-2651.
13. Li, Mengmeng; Du, Zhi-Hong; Bo, Chunbo; Li, Min; Chen, Fei; Liu, Ning. Zn–N3 complexes for the cycloaddition of epoxides with CO2 at atmospheric pressure. New Journal of Chemistry, 2025, 49 (30), 13125-13135.
2024年度：
14. Zhou, Yong-Bo; Chen, Fei; Du, Zhi-Hong; Liu, Bin-Yuan; Liu, Ning. Iron(III) Complexes with Pyridine Group Coordination and Dissociation Reversible Equilibrium: Cooperative Activation of CO2 and Epoxides into Cyclic Carbonates. Inorganic Chemistry, 2024, 63 (35), 16491-16506.
15. Zhang, Nuo; Zhou, Yong-Bo; Chen, Fei; Du, Zhi-Hong; Bo, Chun-Bo; Li, Min; Liu, Ning. Visible-Light-Driven (NSNO)Nickel complex catalyzed (Z)-Selective semi-hydrogenation of alkynes. Fuel, 2024, 383, 133844.
16. Shen, Yangyang; Chen, Fei; Du, Zhi-Hong; Zhang, Hao; Liu, Jichang; Liu, Ning. Cu(I) Complexes Catalyzed the Dehydrogenation of N-Heterocycles. The Journal of Organic Chemistry, 2024, 89 (7), 4530-4537.
17. Luo, Yu-Hui; Tao, Sheng; Chen, Fei; Du, Zhi-Hong; Zhang, Hao; Li, Min; Liu, Ning. Boron–pyridine nitrogen cooperative catalytic conversion of carbon dioxide and epoxides to cyclic carbonates. Catalysis Science & Technology, 2024, 14 (22), 6692-6700.
2023年度：
18. Wang, Yu-Bin; Chen, Fei; Li, Min; Bu, Qingqing; Du, Zhi-Hong; Liu, Jichang; Dai, Bin; Liu, Ning. Visible-light-promoted synthesis of gem-dihaloenones. Green Chemistry, 2023, 25 (3), 1191-1200.
19. Lv, Xiao-Xiong; Liu, Ning; Chen, Fei; Zhang, Hao; Du, Zhi-Hong*; Wang, Pei; Yuan, Meng; Da, Chao Shan. Highly asymmetric aldol reaction of isatins and ketones catalyzed by chiral bifunctional primary-amine organocatalyst on water. Organic & Biomolecular Chemistry, 2023, 21 (43), 8695-8701.
20. Du, Zhi‐Hong*; Lv, Xiao‐Xiong; Liu, Ning; Chen, Fei; Yuan, Meng; Da, Chao‐Shan. Asymmetric Synthesis of Pantolactone: Recent Advances. European Journal of Organic Chemistry, 2023, 26 (46), e202300918.
21. Bo, Chunbo; Chen, Fei; Bu, Qingqing; Du, Zhi-Hong; Li, Min; Dai, Bin; Liu, Ning. Visible-Light-Driven Organocatalytic Alkoxylation of Benzylic C–H Bonds. The Journal of Organic Chemistry, 2023, 88 (6), 3532-3538.
2022年度
22. Du, Zhi-Hong; Da, Chao-Shan; Yuan, Meng; Tao, Bao-Xiu; Ding, Tie-Ying. Efficient Catalyst-Free Henry Reaction between Nitroalkanes and Aldehydes or Trifluoromethyl Ketones Promoted by Tap Water. Synthesis, 2022, 54 (24), 5461-5470.
2021年度
23. Xu, Yan-Li; Qin, Zhou-Zhou; Wang, Yu-Xia; Zhao, Peng-Fei; Li, Hong-Feng; Du, Zhi-Hong; Da, Chao-Shan. Highly enantioselective one-pot sequential synthesis of valerolactones and pyrazolones bearing all-carbon quaternary stereocentres. Organic & Biomolecular Chemistry, 2021, 19 (7), 1610-1615.
24. Wang, Pei; Zhang, Yang; Yang, Hong; Ma, Guo‐Rong; Wang, Jin‐Bao; Yang, Wen; Du, Zhi-Hong; Da, Chao‐Shan. Enantioselective Cross‐Aldol Reaction with Ketones and Non‐Enolizable Ketones Catalyzed by Tetrapeptides. ChemistrySelect, 2021, 6 (30), 7722-7726.
25. Du, Zhi-Hong; Yuan, Meng; Tao, Bao‐Xiu; Qin, Wen‐Juan; Liang, Xiang‐Ming; Li, Yu‐Yan; Lin, Hang; Zhang, Lian‐Chun; Da, Chao‐Shan. Organocatalyzed Highly Enantioselective Aldol Reaction of Aldehydes for Synthesis of (R)‐Pantolactone. Asian Journal of Organic Chemistry, 2021, 10 (5), 1167-1172.
2020年度及以前
26. Han, Zhi-Jian; Zhang, Ze-Xuan; Li, Wei-Ping; Du, Zhi-Hong; Tao, Bao-Xiu; Da, Chao-Shan; Jiao, Zuo-Yi; Chen, Hao; Li, Yumin. Ruthenium-Catalyzed Double C(sp2)−H Functionalizations of Fumaramides with Alkynes for the Divergent Synthesis of Pyridones and Naphthyridinediones. ChemCatChem, 2020, 12 (9), 2538-2547.
27. Du, Zhi-Hong; Tao, Bao-Xiu; Yuan, Meng; Qin, Wen-Juan; Xu, Yan-Li; Wang, Pei; Da, Chao-Shan. Peptide-Catalyzed Highly Asymmetric Cross-Aldol Reaction of Aldehydes to Biomimetically Synthesize 1,4-Dicarbonyls. Organic Letters, 2020, 22 (11), 4444-4450.
28. Du, Zhi-Hong; Qin, Wen-Juan; Tao, Bao-Xiu; Yuan, Meng; Da, Chao-Shan. N-Primary-amine tetrapeptide-catalyzed highly asymmetric Michael addition of aliphatic aldehydes to maleimides. Organic & Biomolecular Chemistry, 2020, 18 (35), 6899-6904.
29. Wang, Pei; Li, Hong-Feng; Zhao, Jia-Zhen; Du, Zhi-Hong; Da, Chao-Shan. Organocatalytic Enantioselective Cross-Aldol Reaction of o-Hydroxyarylketones and Trifluoromethyl Ketones. Organic Letters, 2017, 19 (10), 2634-2637.
八、发明专利：
1. 达朝山; 杜智宏; 陶宝秀; 秦文娟; 袁梦; 白彦兵; 林行; 张连春; 殷杭华; 姜伟林; 余建新; 刘学愚; 金文究，一种手性2-羟基-1,4-二羰基化合物和泛解酸内酯的合成方法，申请(专利)号：CN201910352646.9，授权公告日：2023-09-22.
2. 达朝山，杜智宏，陶宝秀，秦文娟，袁梦，白彦兵，林行，张连春，殷杭华，姜伟林，余建新，刘学愚，金文究，一种手性2-羟基-1,4-二羰基化合物和泛解酸内酯的合成方法。国际公布日，2020-11-05，国际公布号，WO. 2020/220651 A1.
3. Chao-Shan Da, Zhi-Hong Du, Bao-Xiu Tao, Wen-Juan Qin, Meng Yuan, Yanbing Bai, Xing Lin, Lianchun Zhang, Hanghua Yin, Weilin Jiang, Jianxin Yu, Xueyu Liu, Wenjiu Jin, Method for synthesizing chiral 2-hydroxy-1,4-dicarbonyl compound and patlactone, 2022-09-03, EP 3964494 A1.
4. 达朝山，杜智宏，秦文娟，陶宝秀，白彦兵，林行，张连春，殷杭华，余建新，刘学愚，姜伟林，金文究，一种四肽化合物及制备方法和用途，申请(专利)号：CN201811616048.X，授权公告日：2023-07-28。
5. 达朝山，杜智宏，秦文娟，陶宝秀，白彦兵，林行，张连春，殷杭华，姜伟林， 余建新，刘学愚，金文究，一种四肽化合物及制备方法和用途，国际公布日，2020-07-02，国际公布号，WO. 2020/134727 A1.
6. Chao-Shan Da, Zhi-Hong Du, Wen-Juan Qin, Bao-Xiu Tao, Yanbing Bai, Xing Lin, Lianchun Zhang, Hanghua Yin, Weilin Jiang, Jianxin Yu, Xueyu Liu, Wenjiu Jin, Tetrapeptide compound, preparation method and thereof, 2021-03-11, EP 3904367 A1.
7. 达朝山，杜智宏，秦文娟，李玉彦，梁向明，白彦兵，林行，张连春, 一种不对称催化合成光学活性2-羟基-3,3-二甲基-4-氧代丁酸酯的方法，申请(专利)号：CN201810573131.7，授权公告日：2022-04-08.
（2026年1月更新）
